Home Disorders Depression Inflammatory Protein Tied to Depression in DiabetesNow a new study published in the journal Endocrine Connections finds that depression in type 1 diabetes patients is linked to higher levels of an inflammatory protein known as galectin 3.The findings suggest that measuring levels of galectin 3 could be useful for diagnosis of depression or perhaps as a new target for treating depression associated with type 1 diabetes.Galectin 3 is a key protein involved in producing the inflammatory immune system responses that are necessary to repair tissue damage throughout the body in response to injury or disease. However, increased levels of galectin 3 have also been associated with a greater risk of inflammatory disorders such as Alzheimer disease or cardiovascular disease.And although prior research has shown that both depression and diabetes may be linked to increased levels of inflammation in the body, the role of galectin 3 has not been investigated in either condition until now.For the study, the researchers measured the galectin 3 levels of 283 men and women, aged 18 59, with type 1 diabetes, for at least one year. Incidence of depression in these patients was self reported and assessed using the Hospital Anxiety and Depression Scale Depression subscale and possible confounding influences of lifestyle factors including heart disease, smoking or poorly managed diabetes were accounted for in the analysis.The findings revealed that both men and women with type 1 diabetes and depression had significantly higher galectin 3 levels.found that people with type 1 diabetes and depression had higher galectin 3 levels, yet no other diabetes related metabolic changes could account for these elevated levels,” said Dr.
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